Gluten, Low Thyroid and Fibromyalgia

Gluten Intake May Trigger Low Thyroid Function and Lead to Fibromyalgia

I find that 40-50% of my fibromyalga and CFS patients are suffering with low thyroid function. Many of these patients are plagued with Hashimoto's thyroiditis.

Gluten sensitivity has been implicated in contributing to Hashimoto’s Hypothyroidism.

Several studies now show the link between gluten sensitivity and Hashimoto’s hypothyroidism. 

Gluten sensitivity (also known as "gluten intolerance") (GS) belongs to a spectrum of disorders in which gluten has an adverse effect on the body. It can be defined as a non-allergic and non-autoimmune condition in which the consumption of gluten can lead to symptoms similar to those observed in celiac disease.

Symptoms of gluten sensitivity include bloating, abdominal discomfort, pain or diarrhea; or it may present with a variety of symptoms including headaches and migraines, lethargy and tiredness, attention-deficit disorder and hyperactivity, autism and schizophrenia, muscular disturbances as well as bone and joint pain.

Hashimoto's thyroiditis is the most common cause of hypothyroidism in the United States. It is named after the first doctor who described this condition, Dr. Hakaru Hashimoto, in 1912. Hashimoto's thyroiditis is a condition caused by inflammation of the thyroid gland. It is an autoimmune disease, which means that the body inappropriately attacks the thyroid gland--as if it was foreign tissue.

Symptoms of Hashimoto's thyroididitis include anxiety, depression, fatigue, high cholesterol, weight gain, poor immune function, hair loss, cold hands and feet, and constipation.

According thyroid specialist, Dr. Datis Kharrazian, author of “Why Do I Still Have Thyroid Symptoms When My Lab Tests Are Normal?” it’s rare to find a person with Hashimoto’s who doesn’t have some degree of gluten sensitivity or full-blown celiac disease.

Celiac disease is defined generally as an autoimmune response to intestinal tissues upon gluten exposure, as well as overall activation of the immune system.

The list of inflammation-induced symptoms brought on by a gluten sensitivity goes on and depends upon the person’s genetic makeup. Needless to say such systemic inflammation also flares up an autoimmune condition.

Experience shows a gluten-free diet is a must

Dr. Kharrazian writes that “Hashimoto’s patients fall somewhere between gluten sensitivity and celiac disease.  Nevertheless, almost all patients with Hashimoto’s improve on a strict gluten-free diet, even if they do not fit the established criteria of celiac disease. By strict I mean you are 100 percent gluten-free.”

Regular Gluten Testing is Often Inaccurate

Part of the problem with negative gluten antibody tests is improper testing. The general gluten antibody test conducted by most labs today is only testing a small portion of the gluten protein, alpha-gliadin.

In reality, an individual can have an immune response to various parts of the gluten protein, including omega-gliadin, gamma-gliadin, wheat germ agglutinin, and deamidated gliadin.

Both the scientific and clinical evidence linking gluten with Hashimoto’s and autoimmune disease in general is too powerful and abundant to ignore. A strict gluten-free diet is the first and most important step to managing your Hashimoto’s hypothyroidism.

Fish Oil for Fibromyalgia and Chronic Fatigue Syndrome

Essential Fatty Acids (EFAs) for Fibromyalgia and CFS

Essential fatty acids are, as their name implies, essential for our existence.

Essential fatty acids cannot be manufactured by the body and must be obtained from food.They make up the outer membranes of each cell. These membranes determine which nutrients get into and out of the cells. The membranes of healthy cells can resist entry by viruses and other pathogenic agents and, at the same time, facilitate the entry of nutrients-the “happy hormones” serotonin.

When EFAs are deficient, cell membranes are weakened in their abilities, and the wrong substances are allowed into the cell. A deficiency in EFAs can cause some of the very symptoms associated with fibromyalgia and CFS: fatigue, anxiety, depression, GI disorders, muscle pain, insomnia, poor mental function, and lowered immunity. It’s estimated that at least 40% of the population suffers from some amount of EFA deficiency.

There are several interesting interrelationships between EFA metabolism and viral infections (commonly chronic in those with CFS).  EFA’s have direct antiviral effects and are lethal at surprising low concentrations to many viruses. The antiviral activity of human mother’s milk seems to be largely attributable to its EFA content. 

Interferon is dependant on EFA’s and in their absence will be compromised.

 

Viral infections lower the blood levels EFA’s.  This has been confirmed in the case of the Epstein Barr Virus (EBV).  Of particular interest was the observation that at 8 and 12 months, those who have recovered from EBV showed normal or near normal EFA blood levels.  In contrast, those who were still clinically ill from Epstein-Barr show persistently low EFA levels. 

In a Scottish trial, patients with chronic fatigue syndrome were given EFA supplements with great success.  Placebo controlled trials were held for 70 patients with persistent CFS giving them linolenic acid (flax seed oil) and eicosapentaenoic acid (fish oil).  After 6 months, 84% of the patients in the group receiving EFA supplements, and only 22% of those in the placebo group rated themselves as better or much better. 

In another successful study, 63 adults with CFS were enrolled in a double blind placebo controlled study with essential fatty acid therapy.  The patient’s were ill for an average of 1-3 years after a viral infection. They all suffered from severe fatigue, myalgia (muscle pain), and a variety of psychological symptoms.  After one month, 74% of the patients taking EFA supplements, and 23% of those on placebo, assessed themselves as improved.

Depression

A deficiency of Omega-3 fat is one of the main causes of anxiety, depression and other mental disorders.  Omega-3 fats work to keep us mentally and emotionally strong in three ways: 

1) Omega-3 fats act as precursors for the body’s production of pre-prostaglandins and neurotransmitters (specific hormones). 

2) Omega-3 fats provide the substrate for B vitamins and coenzymes to produce compounds that regulate many vital functions, including neurotransmitters.

Omega-3 fats provide energy and nourishment to our nerve and brain cells. 

Eat to reduce inflammation.

The pro-inflammatory hormone PG-2 is made from arachidonic acid (AA).

AA increases bodily inflammation. Since AA is found in corn, and corn products are used as the prominent foodstuff for westernized livestock, red meat, cheese, eggs, and pork products have a high AA content in the United States.

Several research articles have demonstrated that the more animal fats a human eats, the more AA is in his blood and cell membranes and the more likely he is to have inflammation. So reduce your intake of grains and corn-fed livestock.

If your inflammation is severe, reduce or avoid red meat and dairy as well. Cook with olive oil or canola oil. (Avoid instant coffee, as well. It contains substances that block the receptor sites for endorphins.) Vegetables are fine and are encouraged-avoid vegetable oils not vegetables.

The functional opposite of PG-2, PG-1 and PG-3 are anti-inflammatory hormones. They help reduce and eliminate inflammation and pain. You should increase your intake of these hormones. The best sources of PG-1 and PG-3 are fish oil supplements or a diet high in deep cold-water fish.

I recommend taking 2,000 to 4,000mg of fish oil a day.

Chronic Fatigue Syndrome VS. Fibromyalgia

Chronic Fatigue Syndrome VS. Fibromyalgia

Some of the immune disorders associated with CFS are:

• elevated levels of antibodies to various viruses.

• altered helper/suppressor T-cell ratio.

• decreased NK cells or activity.

• decreased levels of circulating immune complexes.

• low or elevated antibody levels.

• increased cytokine levels.

• increased or decreased interferon levels.

• fibromyalgia and multiple chemical sensitivities.5

Chronic Viral Infections and CFS

Individuals who we suspect have chronic fatigue syndrome will have an Epstein Barr Virus EBV and or Cytomegalovirus CMV blood panels drawn. This is to see if there is a virus lingering in the body that is weakening the immune system. These blood tests measure the antibodies immunoglobulin M (IgM) and immunoglobulin G (IgG). A test for IgM antibodies measures the acute (recent infection) phase of the virus. A test for IgG antibodies measures the dormant (inactive) phase of the virus. Our tests also measure Epstein-Barr nuclear antigen (EBNA) antibodies.

►  You don’t have to have a blood test to diagnose CFS. If you’re patient has chronic fatigue (hard to get out of bed each day), achy diffuse pain, and a lowered immune function (chronic infections,) then they either have CFS or they are at high risk of developing the illness.

Due to weakened immunity, individuals with chronic fatigue have terrible problems with energy as well as reoccurring bouts with the flu, colds, sinusitis, and other immune problems.

 As with so many complex chronic illnesses, CFS may be aggravated by a wide variety of environmental and physiological challenges. Food allergies, environmental sensitivities, heavy metal toxicity, yeast overgrowth, intestinal dysbiosis, parasites, and vitamin/mineral deficiencies can all contribute to CFS.

The syndrome’s principal causes are a weakened immune system and a reactivated virus.

All of us have been exposed to mono or the Epstein-Barr virus at one time or another (usually as teenagers), but our bodies are usually strong enough to overcome it. Individuals with CFS have been exposed to the Epstein-Barr virus or mono from some other source, and it has now returned. Its return has either caused the immune system to be compromised or has taken advantage of already compromised immune system.

How to quickly distinguish between FMS and CFS patients.

►  A quick way to distinguish between the two syndrome. 

A positive EBV panel showing elevated antibodies, especially IgM is clear indicator that someone has CFS.

ŸThe CFS patient usually has chronic infections (sinusitis, upper respiratory, UTI’s, colds, flu, etc.) and is sick several times a year. They get at least 2 or more (bad) infections a year. They will usually have chronic or intermittent sore throats, swollen lymph nodes, and periodic fevers. They usually ache all over. 

FMS patients may ache all over as well but usually have specific areas (neck, low back, etc.) that are the most troublesome. 

ŸCFS patients may not have a low serotonin state (“S” on Brain Function Questionnaire, see my book) and will have no problems falling and staying asleep each night.

ŸNote-some of these individuals have a low body temperature (suggestive of low thyroid). They may have a fever when their temperature is at or below 98.6.

Many of these individuals will have a sluggish liver (higher incidence than those with FMS). Clues that would lead you to suspect someone has a sluggish liver include, funny or negative reactions to medications (take something to put them to sleep and it wakes them up or a little goes a long ways), intolerance to caffeine, alcohol, or odors (longer they’ve had illness more sensitive they become to odors, perfumes, gasoline, smoke, cleaners, etc.), and a history of elevated liver enzymes on past blood work. Of course anyone with hepatitis or fatty liver has a sluggish liver. Long term prescription medication therapies can also create a sluggish liver.

True chronic fatigue syndrome patients are a real challenge. Their biochemistry is usually totally shot by the time they get to the right doctor. They can feel better but it requires hard work and requires a lot of patience by the doctor and the patient. 

Fibromyalgia patients aren't easy either but FMS patients respond rather quickly to restoring serotonin levels. Once FMS patients start going into deep restorative sleep, they usually feel better in a matter of days. 

Recommended Disease Allowance

  

RDA Is 50 Years Out Of Date - Could This Be Why America Is So Unhealthy?

The Recommended Daily Allowance is some fifty years out of date.

Many so-called experts will tell you not to worry about taking vitamins if you are eating a balanced diet. Unfortunately, dieting alone can’t provide enough essential vitamins and minerals to promote optimal health.

For instance, you would need to consume 5,000 calories per day (mostly fat) in order to get the recommend minimum (400 IU) of vitamin E, and 12,000 calories per day to get the minimum amount of chromium. Most of our foods are now processed and, therefore, the nutrients have been leeched out of them.  Could this be why pre-senile dementia  and Alzheimer’s is on the rise?

Taking the minimum amount of a nutrient to prevent gross deficiency diseases doesn’t help those people who want to be truly healthy and not just be free of symptoms. 

Almost as unacceptable as not recommending vitamin and mineral supplements is the recommendation of them based on the Recommended Daily Allowance (RDA).  The RDA is the measured amount or dosage of nutrient per vitamin and minerals recommend. The RDA or as it is sometimes called the Recommended Disease Allowance, may keep us from getting Scurvy, but it certainly won’t stand- up to the many chronic diseases that continue to plague modern man.

The RDA is inadequate if the goal is for prevention and or treatment of heart disease, cancer, cataracts, depression, senility, diabetes, arthritis and other age related disorders. For optimal health and wellbeing, many health practitioners are recommending many times higher than the RDA on certain nutrients. It’s no secret, for the majority of the U.S. population the diet is poorly lacking in essential nutrients. 

Additionally, nearly all Americans are deficient even in the minimal RDA requirements, and are therefore exposed to premature death.

Take a look at how just one vitamin/mineral deficiency can lead to poor health-

Vitamin D to the Rescue!

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Vitamin D is one of the oldest hormones, having been produced by life forms for over 750 million years. Phytoplankton, zooplankton, and most plants and animals that are exposed to sunlight have the capacity to make vitamin D. In humans, vitamin D is critically important for the development, growth, and maintenance of a healthy body, from birth until death.

The Institute of Medicine brought experts together recently to explore the question of whether the RDA or recommended daily allowance, of vitamin D has been set too low. The impetus for the occasion was the mounting evidence for this vitamin's role in preventing common cancers, autoimmune diseases, type 1 diabetes, heart disease, chronic pain, and osteoporosis.

Studies show that vitamin D deficiency is common in the U.S.

According to Michael F. Holick, MD, PhD, of the Boston University School of Medicine
the typical symptoms are aching bones and muscle discomfort, vitamin D deficiency is often misdiagnosed as fibromyalgia or chronic fatigue syndrome.

Vitamin D has also been implicated in the cause of various other health disorders including influenza, psoriasis, gout, otosclerosis, interstitial cystitis, decreased pulmonary function, thrombosis, chronic kidney disease, pancreatitis, rheumatology, hepatitis B infections, hemochromatosis, and gastrointestinal diseases.

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Research at a Glance
Autoimmune Illnesses
Autoimmune diseases include rheumatoid arthritis, diabetes, Reiter’s Syndrome. lupus, asthma, and ulcerative colitis. Researchers are discovering an increasing number of links between the immune, nervous, and endocrine systems. Hormones of the endocrine system, such as vitamin D, help the immune and nervous systems defend the body, with defects in this intricate system leading to autoimmune disorders.

Autism
Research has shown that low maternal vitamin D3 has important ramifications for the developing brain. Vitamin D is a steroid hormone with many important functions in the brain, mediated through the nuclear vitamin D receptor (VDR). Dysfunctional VDR demonstrate altered emotional behavior and specific motor deficits.

Cancer
Vitamin D inhibits inappropriate cell division and metastasis, reduces blood vessel formation around tumors, and regulates proteins that affect tumor growth. It also enhances anti-cancer actions of immune system chemicals and chemotherapy drugs.
A four-year study of 1,179 healthy, postmenopausal women showed that taking calcium, along with nearly three times the U.S. government's recommendation of vitamin D3, showed a dramatic 60 percent or greater reduction in all forms of cancer.

It’s estimated that if vitamin D levels were increased worldwide, a minimum of 600,000 cases of breast and other cancers could be prevented each year. Nearly 150,000 cases of cancer could be prevented in the United States alone.

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  Studies show that by taking vitamin D (about 2,000 IU/day) females can cut breast cancer incidence by half!

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Chronic Pain
In a study involving 150 children and adults with unexplained muscle and bone pain, almost all were found to be vitamin D deficient; many were severely deficient with extremely low levels of vitamin D in their bodies.
Vitamin D deficiency causes muscle weakness and pain in children and adults. Muscle pain and weakness was a prominent symptom of vitamin D deficiency in a study of Arab and Danish Moslem women living in Denmark (20).

In a cross-sectional study of 150 consecutive patients referred to a clinic in Minnesota for the evaluation of persistent, nonspecific musculoskeletal pain, 93% had serum 25(OH)D levels indicative of vitamin D deficiency.

Osteoporosis
Maintenance of serum calcium levels within a narrow range is vital for normal functioning of the nervous system, as well as for bone growth, and maintenance of bone density. Vitamin D is essential for the efficient utilization of calcium by the body.
A recent study found that supplementation of elderly women with 800 IU/day of vitamin D and 1,200 mg/day of calcium for three months increased muscle strength and decreased the risk of falling by almost 50% compared to supplementation with calcium alone.

Mental Function and Moods
Recent research indicates vitamin D deficiency is associated with low mood and cognitive impairment in the elderly. Vitamin D deficiency has been implicated in various psychiatric disorders including anxiety and depression.

Diabetes
Vitamin D helps maintain adequate insulin levels. Preliminary evidence suggests supplementation can increase insulin levels in people with type 2 diabetes. Prolonged supplementation may help reduce blood sugar levels.

Immune Function
There is considerable scientific evidence that 1,25(OH)2D has a variety of positive effects on boosting the immune system.
Additionally, there is growing evidence that maintaining vitamin D levels in the body during the winter prevent the flu and other viral infections by strengthening the immune system.

Heart Disease
Activated vitamin D has been shown to increase survival in patients with cardiovascular disease.
Hyperparathyroidism
Low plasma vitamin D3 has been found to be a major risk factor for hyperparathyroidism.

High Blood Pressure
Clinical and experimental data support the view that vitamin D metabolism is involved in blood pressure regulation and other metabolic processes.

Melanoma
An inability to tan is the number one risk factor for melanoma. Those who tan easily or who have darker skin are far less likely to develop the disease. A new theory is that melanoma is actually caused by sunlight (vitamin D) deficiency and that safe sun exposure actually helps prevent the deadly disease.

Multiple Sclerosis
Vitamin D supplementation may help prevent the development of MS as well as provide for additional treatment.

Osteoarthritis
Low intake and low serum levels of vitamin D appear to be associated with an increased risk for progression of osteoarthritis.

Osteoporosis
Vitamin D deficiency is extremely prevalent in the elderly. Most often the first symptoms are muscle pain, fatigue, muscular weakness, and gait disturbances. More severe deficiency causes osteomalacia (bone weakening and loss) with deep bone pain, reduced mineralization of bone matrix, and bone fractures.


How much vitamin D does the average person need?

In the summer, those with at least 15 minutes of sun exposure on their skin most days should take around 1,000 mg of vitamin D3 each day. In the winter, those with dark skin, or those who have little sun exposure on their skin, should take up to 4,000 mg each day. Those who have darker skin, are older, avoid sun exposure or live in the northern US should take the higher amounts, around 2,000mg a day.

Vitamin D is remarkably safe; there have been no deaths caused by the vitamin.
People consuming only government-recommended levels of 200-400 IU/day
often have blood levels considerably below 50 ng/ml. This means the government’s recommendations are too low, and should be raised for optimal health function.

High Dose Vitamin D can be purchased at a number of health food or big name drug stores. However, please be advised that not all vitamin D is equal. I recommend using only pharmaceutical grade, naturally-occurring Vitamin D3.

The Verdict is in-Cholesterol Drugs are Dangerous

Statin lipid lowering drugs including Levacor, Zocor, Pravachol, Lipitor, and Crestor, are some of the most widely prescribed drugs in the world. In fact, the propaganda for these medications has been so hyped for lowering cholesterol that some doctors have advocated they should be sold over-the-counter like aspirin or worse placed in our drinking water. Others want children as young as two to be on these drugs as a way to prevent elevated cholesterol!

Before you fall victim to the propaganda, you should know that  scientist’s from the University of California (UC) San Diego School of Medicine have published a review paper setting the record straight.

Analyzing the nearly 900 research studies on statins to see just what the facts are. The verdict? The drugs may predispose many people to serious muscle and kidney problems, potentially deadly heart arrhythmias, depression, fatigue, muscle pain, dementia, and a host of other health problems.

The paper, co-authored by Beatrice Golomb, MD, PhD, associate professor of medicine at the UC San Diego School of Medicine and director of UC San Diego's Statin Study group, and Marcella A. Evans, of UC San Diego and UC Irvine Schools of Medicine, was published in the on-line edition of the American Journal of Cardiovascular Drugs.

It provides the most comprehensive look to date of not only the reported side effects of statins, but the evidence of how these side effects are caused by the drugs. The paper also offers explanations as to why certain people on these medication are at increased risk for adverse reactions.

For example, the paper points to accumulated data showing higher statin doses and statin drugs with the strongest ability to lower cholesterol are linked to the greatest risk of developing side effects. Certain genetic conditions have also been found to place people at higher risk for serious problems from the prescription medications.

"Muscle problems are the best known of statin drugs' adverse side effects," Dr. Golomb said in a media statement. "But cognitive problems and peripheral neuropathy, or pain or numbness in the extremities like fingers and toes, are also widely reported." In addition, the paper discusses other negative health effects from the drugs, including irregular heartbeats, elevated blood glucose, and tendon problems.

Specifically, the review of statin research found powerful evidence that statins induce injury to mitochondria, membrane-enclosed organelles often described as "power plants" inside the body's cells. They generate adenosine triphosphate (ATP), which is used as a source of cells' chemical energy. So by interfering with this pathway, statins may cause many of the adverse effects that occur to people taking the medications. With injured mitochondria, the body produces less energy and more "free radicals" are produced.

As they block the production of cholesterol in the body, statins also block the production of much of the body's coenzyme Q10 (Co-Q10), a compound important to the process of making energy within mitochondria and also to stopping free radical damage. In addition, statins reduce the very blood cholesterol that is needed to carry Co-Q10 and other fat-soluble antioxidants throughout the body.

Hypertension and diabetes -- as well as advancing age -- are independently linked to higher rates of mitochondrial problems and associated with a higher risk of statin complications, too.

"The risk of adverse effects goes up as age goes up, and this helps explain why," Dr. Golomb said in the media release. "This also helps explain why statins' benefits have not been found to exceed their risks in those over 70 or 75 years old, even those with heart disease."

Did you know you are likely to die from all causes with low cholesterol than high cholesterol? Did you know that statin drugs reduce the risk of heart attack and stroke by a whopping one percent?

You can read more about the medical myths of hear disease and why the AMA’s propaganda is flat out wrong at the link below-

http://drmurphree.blogspot.com/2010/08/medical-myths-of-cholesterol-what-you.html